I know the mechanism is inhibiting gastric and pancreatic lipase so less fat can be absorbed but my question is can this be done with a single dose or does it require a period of multiple intakes before the lipase are fully inhibited over time.
I guess what I'm really asking is can a single dose(120mg) of Orlistat inhibit gastric and pancreatic lipease short-term so the effect of a 25-30% reduction of fatty acid absorption in the intestines is achieved or does the compound need to be taken longer for the lipease enzymes to inhibited?
Thank you. Do you know where I can find more information on the pharmadynamics and kinetics of this drug?
I guess what I'm really asking is can a single dose(120mg) of Orlistat inhibit gastric and pancreatic lipease short-term so the effect of a 25-30% reduction of fatty acid absorption in the intestines is achieved or does the compound need to be taken longer for the lipease enzymes to inhibited?
Thank you. Do you know where I can find more information on the pharmadynamics and kinetics of this drug?
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Orilistat (Xenical, Alli) is a reversible inhibitor of lipase meaning it only exerts its effects while the drug is present. There is no such thing as 'full inhibition over time'. Taken three times a day, orlistat inhibits dietary fat absorption by approximately 30% over a 24 hour period. A single dose will have a shorter, transient effect.
PS: There are still plenty of us older Pharmacists with a BSPharm out there working.
PS: There are still plenty of us older Pharmacists with a BSPharm out there working.