Theoretically yes. There are some void zones in the universe. Otherwise no, because there are always neutrino's etc. going through parts of space.
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There's no perfect, absolute vacuum. Inter-galactic space doesn't even qualify. Actually, science can make a vacuum closer to absolute than exists anywhere in nature. Even at size scales of 0.000000000000000000000000000000000016 meters (...the Planck Length...) so-called virtual particles are constantly popping in and out of existence.
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Well of course. Take a 1ft long test tube, fill it with mercury and turn it upside down without letting any of the mercury out and put it into a pool of mercury and the weight of the mercury will produce a perfect vacum.
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Dyson ball