Acceleration and Space

Can you accelerate in space even in the absence of an atmosphere?

In a vacuum, you can accelerate as long as you can generate energy, just not via pressure differences between the body and the "air".

This is why rockets can accelerate, because combustion creates a difference in pressure between the '0' pressure of space and the high pressure of a combustion engine, causing a net force on the body to which the engine is connected, for example.

yes, there is nothing holding so as long as you got a way to accelerate
you can move.