Is there life out there

The correct answer is: we do not know.

We have no proof that life exists elsewhere in the universe.
We have no proof that life does not exist elsewhere in the universe.

We do have a statistical analysis result that appears to show that the "probability of life elsewhere" tends to 100%, but we (statisticians) know that such a result is NOT a proof, just an indicator.

A better approach is to ask if there is life out there that is close enough and advanced enough that we could, one day, find out about them (even if all we do is find out they exist). The Drake equation gives us an idea for that (but no proof).

However, many factors in the Drake equation are still guesses (even though some are "educated guesses"). When used in its original form, the Drake equation gives the number of intelligent civilizations "capable of communicating", within an average galaxy.

I remember very optimistic results back in the 1960s (up to 100,000 civilizations per galaxy) and very pessimistic results near the end of the 1970s (including one by Carl Sagan himself) that gave a result of:

1/4 civilization per average galaxy (our Galaxy being taken as the average).

This means that we could be the only civilization in the whole Local Group.

Sure, there could be some life out in the Hercules cluster, but at a distance of 650 million light-years, this would make for very slow conversations.

There is no indication that there is.

There is no evidence to think there isn;t.

All we know for sure is, it's a big universe, with a lot of stars and planets. But, it is a big universe, with unimaginable distances between the stars and planets.

Liove might be out there, but it is just as likely that we will never be able to cover the "distance problem" to find out for sure... even at light speed, we wouldn't detect life in the Andromeda Galaxy until at least 2 Million years after it sent its first signal out in space.