These theories of hand preference causation are intriguing because they can account for the fact that the side of hand preference of individuals with the C gene (most left-handers and some right-handers) can be influenced by external cultural and societal pressures, a phenomenon that researchers have documented. These theories can also explain the presence of right-handed children in families with left-handed parents and the presence of left-handed children in families with right-handed parents. If the familial genetic pool contains C genes, then hand preference becomes amenable to chance influences, including the pressures of familial training and other environmental interventions that favor the use of one hand over the other. The proposed genetic locus that determines hand preference contains an allele from each parent, and the various possible genetic combinations are DD individuals who are strongly right-handed, DC individuals who are also mostly right-handed, and CC individuals who are either right-handed or left-handed. These genetic combinations leave us with an overwhelming majority of human right-handers and a small, but persistently occurring, minority of left-handers.
