Is it possible that a mild dose of bupropion will cause a significant increase in craving for alcohol
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Is it possible that a mild dose of bupropion will cause a significant increase in craving for alcohol

[From: ] [author: ] [Date: 13-02-16] [Hit: ]
The combination of bupropion (100 mg) and two drinks of alcohol increased heart rate by six beats per minute, a statistically significant increase.Though keep in mind, the way one feels after drinking doesnt indicate the level of soberness that is actually occurring.Antidepressants are notorious for altering the perception of inebriation caused by alcohol both ways........
It is possible. This is not a 'common' reaction however.

There are somewhat common interactions with buproprion (wellbutrin) with alcohol.

Many report that it lowers their tolerance to alcohol to some degree and some even report that it increases the 'euphoria' while drinking alcohol. Which may just be attributed to their tolerance being significantly lowered,.. though it works in similar areas of the brain as alcohol so their may be a synergistic effect occurring.

There have been studies by GlaxoSmithKline one alcohol use and buproprion and most commonly the users reported that the two mixed together caused them to :

"feeling more sober and clear-headed and less sedated. Bupropion also reduced the detrimental effect of alcohol on auditory vigilance. The combination of bupropion (100 mg) and two drinks of alcohol increased heart rate by six beats per minute, a statistically significant increase."

Though keep in mind, the way one 'feels' after drinking doesn't indicate the level of soberness that is actually occurring. Antidepressants are notorious for altering the perception of inebriation caused by alcohol both ways.. in some more perceived inebriation, and in others less perceived inebriation.

It is good you are recognizing this trait -- Buproprion can increase anxiety, though this effect generally reverses to a decrease in anxiety over time as the brain adapts and side effects diminish. This can be responsible for an increase in alcohol consumption. Though I do not know how long you have been regularly taking buproprion, but 2 weeks is still in the range of the body 'adjusting' to the side effects'.

So my advice, if it is having a positive impact in your life/mental health/mood/emotions -- to then just be vigilant with your alcohol consumption realizing this is somewhat of a catalyst to an increase in alcohol consumption. If you can discipline yourself, I think the benefits outweigh this effect. Unless you have a history or alcohol abuse/addiction.

Take care,

-
You need to know that these chemicals alter your brain chemistry. Stuff like this can happen. I'd tell your psychiatrist and possibly change medications as this may have serious side effects.
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