Most people should take Bupropion Hydrochloride Extended-Release Tablets, USP (SR) for at least 7 to 12 weeks. Some people may need to take Bupropion Hydrochloride Extended-Release Tablets, USP (SR) for a longer period of time to assist in their smoking cessation efforts. Follow your doctor's instructions. When should I stop smoking? It takes about 1 week for Bupropion Hydrochloride Extended-Release Tablets, USP (SR) to reach the right levels in your body to be effective. So, to maximize your chance of quitting, you should not stop smoking until you have been taking Bupropion Hydrochloride Extended-Release Tablets, USP (SR) for 1 week. You should set a date to stop smoking during the second week you're taking Bupropion Hydrochloride Extended-Release Tablets, USP (SR).