Can plants evolve against humans

I know that plants have adapted to things in nature, such as predatorial factors. Such as evolving their color, or etc.
But what I'm asking is have plants evolved defense mechanisms against humans yet? Is it possible?

Depends on what you consider a "defense mechanism against humans."

Plenty of plants are produce toxic/poisonous to human consumption. You also have thorns and such.

Many plants have also adapted to our agricultural practices. Many weeds germinate and flower faster, and some are herbicide-tolerant. Selection and evolution happens quickly - if you look at a lawn that is mowed often, the dandelions are shorter than a lawn that is allowed to grow out more.