Pyruvate+CoA+NAD+---------->acetylCoA+CO…
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Oxidation is loss of electrons
(and in these reaction a proton is lost with each electron),
so these oxidations are the loss of H atoms.
Reduction, then is the gaining of electrons (and protons, so ).H atoms.
Therefore, pyruvate and CoA are oxidized (pyruvate is also decarboxylated):
CH3COCOOH and CoASH become CH3CO- and CoAS- (+ 2H + CO2)
then THEY combine to make CoAS-COCH3
and
NAD+ is reduced:
NAD+ + 2H become NADH + H+
(and in these reaction a proton is lost with each electron),
so these oxidations are the loss of H atoms.
Reduction, then is the gaining of electrons (and protons, so ).H atoms.
Therefore, pyruvate and CoA are oxidized (pyruvate is also decarboxylated):
CH3COCOOH and CoASH become CH3CO- and CoAS- (+ 2H + CO2)
then THEY combine to make CoAS-COCH3
and
NAD+ is reduced:
NAD+ + 2H become NADH + H+