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Sickle cell hemoglobin and normal hemoglobin have only one amino acid residue difference: the normal's glutamic acid residue is replaced by the sickle's valine residue.
The result is a hemoglobin molecule which stacks hydrophobically, causing the misshapen sickle cells.
The result is a hemoglobin molecule which stacks hydrophobically, causing the misshapen sickle cells.