Heres the problem: http://tinypic.com/r/a59306/5
I'm stuck with the first step. I have no idea what reagent to use and the structure it will become.
I'm stuck with the first step. I have no idea what reagent to use and the structure it will become.
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The first step requires a Grignard reaction. So the reagent would be an Mg/ether solution. The Grignard reagent would then attack the ethylene oxide (oxirane) and open the epoxide. Addition of H+ would protonate the O- to form an alcohol. Then you would use PCC to oxidize the alcohol into an aldehyde.
It's hard to write the synthesis here but it should look something like this:
PhCH2Br (1. Mg/ether) > PhCH2MgBr
PhCH2MgBr (1. Oxirane 2. H+) > PhCH2CH2CH2OH
PhCH2CH2CH2OH (1. PCC) > PhCH2CH2CH=O
It's hard to write the synthesis here but it should look something like this:
PhCH2Br (1. Mg/ether) > PhCH2MgBr
PhCH2MgBr (1. Oxirane 2. H+) > PhCH2CH2CH2OH
PhCH2CH2CH2OH (1. PCC) > PhCH2CH2CH=O