When we first went to the Moon, how many people were actually on the space shuttle

as other's have said it was just 3. Just to be pedantic though, The craft that made the journey to the moon was a lunar module with an attached lander which were one time use only vehicles. Space shuttles came later, and were designed specifically to make repeated trips to earth orbit.

The Apollo space craft was not a shuttle. It was launched on a Saturn V rocket and had 3 modules and a crew of 3 astronauts. The Lunar Module was the only part to land on the Moon and it carried 2, while the 3rd astronaut orbited the Moon in the Command module. The service module was the last stage of the rocket and provided the power to decelerate all three modules into Lunar orbit, and then send the command module with all 3 in it back to Earth. The Lunar Module was abandoned at the Moon.

The Space Shuttle was a later program to send winged space planes that could be reused into Earth orbit. All the Saturn stages and Apollo modules (except the Command module) were abandoned in space. Only the Command module parachuted back to Earth but it was never used for more than one flight. All new rockets and modules were built for each Apollo flight.

Zero. No space shuttle was used in the Apollo program. In fact, the first space shuttle wasn't built until 9 years after the Apollo program finished. Space shuttles are lame devices designed to get people and materials into low Earth orbit and back to Earth, and have no capability of travelling to the Moon. The Apollo Moon missions used much more powerful and sophisticated delivery systems than the shuttle. Each Apollo mission (six landed on the Moon) carried three astronauts, of which one stayed in lunar orbit while the other two landed. But NO space shuttles were involved!

The first manned Apollo spacecraft was launched in 1968. The first one that went to the Moon also went in '68. The first Apollo that had a Lunar Module that landed on the Moon flew in July of '69. The last such Apollo that landed on Moon flew in December of '72.