How much energy is needed to destroy the Milky Way

Assuming an explosion was set off at the center of the Milky Way Galaxy, how much energy (in Joules) is needed to destroy it by brute force alone?

Depends on what you mean by "destroy", and what sort of explosion. Something around 10^59 joules should do the job. Maybe as little as 10^57 J, if the explosion was carefully designed. That's about 10^48 J for each star (on average). The explosion would need to push the stars and gas outwards, not waste its energy as light and neutrinos escaping the galaxy.

Of course, it would take many million years for the galaxy's stars to be pushed outwards enough so that somebody could say that the galaxy had been destroyed.

Well, you could use gravity to squeeze everything smaller than an atom and then they will be black holes which would "suck" everything up

9001 joules

12,21,2012 Joules. It has to be a coincidence.

If you could find away to give God shrooms you could destroy the universe

You need the force of 10000000000000000000000000000 gods